Expert in vitro and genotoxicity testing, Director of Gentoxicon (Belgium)
Philippe Vanparys graduated in 1977 as biologist at the State University of Ghent (RUG, Belgium) and joined in 1978 the Janssen Research Foundation (JRF) in Beerse (Belgium). He established the genetic toxicology unit and became head of this department. In 1979, he organised the switch of his department from non-GLP to GLP compliance and has >30 years of experience in conducting studies according to the GLP regulations. He gained his PhD in Science in 1988 at the Catholic University of Louvain (Belgium). In 1990, he established an in vitro toxicology laboratory with focus on the development of alternative methods to replace and reduce the use of laboratory animals in toxicology testing.
- He was appointed in 1991 Director of Genetic and In Vitro Toxicology and was responsible for regulatory toxicology as well as for alternative toxicology testing. He also established in silico and high throughput screens for primary screening of genetic toxicity for the Discovery Research at JRF. At the alignment of the Pharmaceutical Research Institute (USA) with the Janssen Research Foundation in 2000, he was appointed as Senior Research Fellow and Head of the Genetic and In vitro Toxicology at Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) in Beerse (Belgium).
- In 2003, he was the Belgian Representative in the OECD Task Force to provide guidance for the appropriate application of the GLP Principles to in vitro studies. He was asked at J&JPRD to established in 2005 a centre of Excellence on Mechanistic Toxicology and was appointed as “EU Head Mechanistic Toxicology”.
- In April 2008, he left J&JPRD and raised a consulting company ALTOXICON BVBA on alternatives for animal testing and genetic toxicology. As consultant he was appointed Managing Director at the Centre for Advanced Research and Development on Alternative Methods (CARDAM, VITO NV, Belgium). As expert in the field of alternatives he was during the second half of 2008 detached for one week per month to ECVAM (Ispra, Italy) to give assistance to the Director of the EU Joint Research Centre (JRC) Institute for Health and Consumer Protection (IHCP, Ispra, Italy).
- In 2011, he resigned as Managing Director at CARDAM. As his activities were at leaving CARDAM, for 100% directed towards genetic toxicology testing, he closed in 2014 ALTOXICON BVBA and raised GENTOXICON BVBA focusing mainly on genetic toxicology. He has 37 years experience in genotoxicity testing.
- He was elected President of the Belgian Environmental Mutagen Society (BEMS) in 1991, was involved in several ECVAM Taskforces and was member of the team performing the retrospective validation of the in vitro micronucleus test resulting in a worldwide accepted alternative test for genotoxicity testing. He was chairman of the prevalidation study of the cell transformation tests and member of the ICCVAM Ocular Expert Panel (USA) in 2005 and 2009.
- He is currently member of the Genotoxicity Testing Advisory Committee (GTAC) of the International Organization of the Flavor Industry (IOFI) to help the association in registration of flavors for food and feed products. He was co-founder of the Dutch-Belgian INVITROM association. He is currently board member and treasurer of the European Consensus Platform for Alternatives (ECOPA), board member of BELTOX and the Alexandra Association (Monaco) and member of the Scientific Advisory Board of ATERA.
- He is certified as European Registered Toxicologist (ERT) and Guest Professor at Thomas More (Campus De Nayer and KAHO Technology Campus Ghent) of the K.U.Leuven Association. In 2005, he and two of his collaborators received the first J&J 3Rs Award in Recognition of Advancing the 3Rs at J&J. Currently, he is at Janssen Research and Development (Beerse, Belgium) member of the Ethical Committee on Animal tests focusing on implementation of the 3Rs in Discovery and Developmental research
- He is author and co-author of 80 publications and several hundreds non-clinical study reports on genotoxicity testing and alternatives on animal testing